The game begins shortly after the events of Assassin's Creed II, in the year 1499. Monterigoni is besieged by the Borgia clan, lead by Rodrigo's son Cesare Borgia. During the battle Ezio's uncle, Mario, is killed and the Apple of Eden is taken by Borgia. Ezio, now the Grand Master of the Assassin's Order, seeks revenge and heads to Rome to take the fight to the Templar Order.
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